2166-32-7

Basic information

• Product Name: 6-(P-TOLYL)-3(2H) PYRIDAZINONE
• Synonyms: 6-(P-TOLYL)-3(2H) PYRIDAZINONE;6-(4-METHYLPHENYL)-3(2H)-PYRIDAZINONE;6-(4-METHYLPHENYL)PYRIDAZIN-3(2H)-ONE;6-(p-tolyl)pyridazin-3(2H)-one
• CAS NO: 2166-32-7
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 2166-32-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 220-221 °C
• Boiling Point: 405.5°C at 760 mmHg
• Flash Point: 199.1°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 3.72E-07mmHg at 25°C
• Refractive Index: 1.609
• PKA: 11.12±0.40(Predicted)
• CAS DataBase Reference: 6-(P-TOLYL)-3(2H) PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(P-TOLYL)-3(2H) PYRIDAZINONE(2166-32-7)
• EPA Substance Registry System: 6-(P-TOLYL)-3(2H) PYRIDAZINONE(2166-32-7)

Safety Data

• Hazardous Substances Data: 2166-32-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2O/c1-8-2-4-9(5-3-8)10-6-7-11(14)13-12-10/h2-7H,1H3,(H,13,14)

Upstream product

• 1079-72-7 6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 1236309-68-4 3-benzylamino-5-(4-methylphenyl)furan-2(3H)-one 
• 52348-05-7 2-benzylamino-4-(4-methylphenyl)-4-oxobutanoic acid 
• 20972-36-5 4-(p-methylphenyl)-4-oxo-2-butenoic acid 
• 124-38-9 carbon dioxide 
• 878625-20-8 β-(p-toluoyl)-α-(1,2,4-triazol-1-yl)propionic acid 
• 108571-56-8 β-(4-methylbenzoyl)-α-(N-imidazolyl)propionic acid 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 86894-60-2 2-(6-oxo-3-p-tolylpyridazin-1(6H)-yl)acetamide 
• 853330-48-0 methyl 2-(6-oxo-3-p-tolylpyridazin-1(6H)-yl)acetate 
• 58112-52-0 ethyl 2-(6-oxo-3-p-tolylpyridazin-1(6H)-yl)acetate 
• 1177257-70-3 2-allyl-6-p-tolylpyridazin-3(2H)-one 
• 1177257-71-4 2-(prop-2-ynyl)-6-p-tolylpyridazin-3(2H)-one 
• 922974-68-3 ethyl 2-(6-oxo-3-p-tolylpyridazin-1(6H)-yl)propanoate 
• 1443124-84-2 N⁴,N⁴-diethyl-N¹-(3-((6-oxo-3-(p-tolyl)pyridazin-1(6H)-yl)methyl)phenyl)piperidine-1,4-dicarboxamide 
• 93637-30-0 C₃₆H₂₈N₈O₂ 
• 93637-34-4 2-[5-(4-Methoxy-phenyl)-1-phenyl-1H-[1,2,4]triazol-3-yl]-6-p-tolyl-2H-pyridazin-3-one 
• 93637-32-2 2-(1,5-Diphenyl-1H-[1,2,4]triazol-3-yl)-6-p-tolyl-2H-pyridazin-3-one 
• 93637-28-6 6-p-tolyl-3-oxopyridazin-2-hydrazidoyl chloride 
• 93637-26-4 6-Oxo-3-p-tolyl-6H-pyridazine-1-carboxylic acid N'-phenyl-hydrazide 
• 58112-67-7 2-chloromethyl-6-p-tolyl-2H-pyridazin-3-one 
• 2165-06-2 3-(4-methylphenyl)-6-chloropyridazine 

Relevant articles and documents

Features of reactions of (E)-[(2-aroyl)ethenyl]triphenylphosphonium bromides with binucleophiles

Reactions of (E)-[(2-aroyl)ethenyl]triphenylphosphonium bromides with hydroxylamine hydrochloride resulted in the formation of oximes undergoing α-phenyl migration when reacted with aqueous alkali. Reaction of these salts with hydrazine hydrochloride and

3(2H)-pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition

New ten compounds bearing pyridazinone ring (5a–j) were designed and synthesized as acetylcholinesterase inhibitors. The new derivatives were acquired via the reaction of propionohydrazides with substituted/nonsubstituted sulphonylchlorides. The structures of the synthesized compounds were explained using FT-IR, 1H-NMR, 13C-NMR, elemental analysis and HRMS spectra. The inhibition profiles of the synthesized compounds on AChE were researched by comparing their IC50 and KI values. According to the activity studies, all the compounds showed significant inhibitory activity against AChE relative to the reference compound Tacrine. The compound 5g showed the best acetylcholinesterase inhibitory effect with a KI value of 11.61 ± 0.77 nM. For all compounds, the parameters of the interaction points on the receptor side were determined on the ligand basis with the 4D-QSAR model. The synthesized pyridazinone derivatives, 5(a-j), were screened for their acetylcholinesterase inhibitory potential, and the results determined that among the series, compounds 5g, 5f and 5j showed the best inhibition, respectively. For anti-Alzheimer activities, 5g, 5f and 5j compounds were performed in silico studies to understand the binding site, binding energy properties in molecular docking.

Synthesis of some new pyridazin-3-one derivatives and their utility in heterocyclic synthesis

(Chemical Equation Presented) Synthesis of new heterocyclic compounds containing the pyridazinone moiety, which have a valuable biological activities, has been achieved through the nucleophilic addition of benzylamine to 4-(p-substituted phenyl)-4-oxo-2-b