1443125-01-6

Basic information

• Product Name: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide
• Synonyms: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide
• CAS NO: 1443125-01-6
• Molecular Weight: 544.697
• Mol File: 1443125-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide(1443125-01-6)
• EPA Substance Registry System: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide(1443125-01-6)

Safety Data

• Hazardous Substances Data: 1443125-01-6(Hazardous Substances Data)

Upstream product

• 1452128-54-9 C₁₃H₁₅N₃O 
• 619-23-8 3-Nitrobenzyl chloride 
• 1903-67-9 N,N-diethylpiperidine-4-carboxamide 
• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant articles and documents

Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors

2,6-Disubstituted pyridazinone 4 was identified by HTS as a novel acetylcholinesterase (AChE) inhibitor. Under SAR development, compound 17e stood out as displaying high AChE inhibitory activity and AChE/butyrylcholinesterase (BuChE) selectivity in vitro. Docking studies revealed that 17e might interact with the catalytic active site (CAS) and the peripheral anionic site (PAS) simultaneously. Based on this novel binding information, 6-ortho-tolylamino and N-ethyl-N-isopropylacetamide substituted piperidine were disclosed as new PAS and CAS binders.