1443126-81-5

Basic information

• Product Name: 8-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine
• CAS NO: 1443126-81-5
• Molecular Weight: 246.656
• Mol File: 1443126-81-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine(1443126-81-5)
• EPA Substance Registry System: 8-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine(1443126-81-5)

Safety Data

• Hazardous Substances Data: 1443126-81-5(Hazardous Substances Data)

Upstream product

• 68774-77-6 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine 
• 106-48-9 4-chloro-phenol 

Relevant articles and documents

Synthesis and studies on anticonvulsant activity of 8-alkoxy-[1,2,4] triazolo[4,3-a]pyrazine

In this study, a series of new 8-alkoxy-[1,2,4]triazolo[4,3-a]pyrazine derivatives were synthesized and their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock test and the rotarod test, respectively. The most promising compounds 3d (8-butoxy-[1,2,4]triazolo[4,3-a] pyrazine) and 3f (8-hexyloxy-[1,2,4]triazolo[4,3-a]pyrazine) showed a median effective dose of 44 and 35.3 mg/kg and had protective index value of 3.2 and 4.8, respectively. To explain the possible mechanism of anticonvulsant activity, all compounds were tested in chemical induced model in anti pentylenetetrazol test.