68774-77-6

Basic information

• Product Name: 8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
• Synonyms: 8-CHLOROTRIAZOLO[4,3-A]PYRAZINE;8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE;1,2,4-Triazolo[4,3-a]pyrazine,8-chloro-
• CAS NO: 68774-77-6
• Molecular Formula: C₅H₃ClN₄
• Molecular Weight: 154.56
• Mol File: 68774-77-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 215-220℃
• Appearance: Brown/Solid
• Density: 1.716 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.10±0.30(Predicted)
• CAS DataBase Reference: 8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE(68774-77-6)
• EPA Substance Registry System: 8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE(68774-77-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 68774-77-6(Hazardous Substances Data)

Usage

General Description

8-Chloro-[1,2,4]triazolo[4,3-a]pyrazine is a chemical compound, part of the azines, heterocyclic compounds that contain one or a few nitrogen atoms that replaced the carbon atoms in the ring structure. Like other azines, it often functions as a core structure in the pharmaceutical industry due to its high nitrogen content and versatile reactivity. This specific compound is potentially involved in a variety of chemical reactions due to its unique chloro and triazolo groups. The compound, however, may not be fully explored yet, and further studies might be needed to fully understand its properties and potential uses.

Upstream product

• 63286-28-2 2-chloro-3-hydrazinopyrazine 
• 149-73-5 trimethyl orthoformate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 837430-14-5 5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)-pyrazine hydrochloride 
• 1154096-48-6 (2R,3,S)-3-([1,2,4]triazolo[4,3-a]pyrazin-8-ylamino)-4-(3,5-difluorophenyl)-1-((R)-2,2-spirocyclobutane-6-neopentyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-4-ylamino)butan-2-ol 
• 1154096-49-7 (2R,3,S)-3-([1,2,4]triazolo[4,3-a]pyrazin-8-ylamino)-1-((R)-6-bromo-2,2-spirocyclobutanechroman-4-ylamino)-4-phenylbutan-2-ol 
• 1154096-44-2 (2R,3S)-4-(3,5-difluorophenyl)-1-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-3-([1,2,4]triazolo[4,3-a]pyrazin-8-ylamino)-2-butanol 
• 1443126-74-6 8-(2-tolyloxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-75-7 8-(3-tolyloxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-76-8 8-(4-tolyloxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-77-9 8-(2-methoxyphenoxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-78-0 8-(4-methoxyphenoxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-80-4 8-(3-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-81-5 8-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1443126-83-7 8-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1025950-29-1 [3-(5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Discovery of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing a 4-oxo-pyridazinone moiety as potential c-Met kinase inhibitors

Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moieties (compounds21a-land22a-l) were designed and their IC50values were evaluated against three cancer cell lines (A549, MCF-7 and HeLa) and c-Met kinase. Among them, the compound with most potential,22i,exhibited excellent anti-tumor activity against A549, MCF-7 and HeLa cancer cell lines with IC50values of 0.83 ± 0.07 μM, 0.15 ± 0.08 μM and 2.85 ± 0.74 μM, respectively, and it also possessed superior c-Met kinase inhibition ability at the nanomolar level (IC50= 48 nM). Moreover, dose-dependent experiments, AO fluorescence staining, cell cycle assay, Annexin V-FITC/PI staining and docking studies were carried out in this study. The results demonstrated that compound22icould be a potential c-Met kinase inhibitor.

Triazolo pyrazine compound containing heteroaryl substituted pyridazinone structure, and preparation method and applications thereof

The invention relates to a triazolo pyrazine compound containing a heteroaryl substituted pyridazinone structure, and pharmaceutically acceptable salts, hydrates, solvates, and a prodrug thereof, wherein the triazolo pyrazine compound containing a heteroa