1443141-69-2Relevant academic research and scientific papers
Preparation of the zinc enolate equivalent of amides by zinciomethylation of isocyanates: Catalytic asymmetric Reformatsky-type reaction
Haraguchi, Ryosuke,Matsubara, Seijiro
, p. 2272 - 2282 (2014)
Bis(iodozincio)methane [CH2(ZnI)2] transforms isocyanates (R-N=C=O) into the enolate equivalent of amides via zinciomethylation. The reactivity of the enolate equivalent as a nucleophile toward aldehydes depends on the R group of the
Catalytic asymmetric aldol-type reaction of zinc enolate equivalent of amides
Haraguchi, Ryosuke,Matsubara, Seijiro
supporting information, p. 3378 - 3380 (2013/07/26)
Treatment of phenyl isocyanate with bis(iodozincio)methane gave a zinciomethylenated product, which acts as an amide-enoate equivalent. It did not react with an aldehyde efficiently, but gave the corresponding adduct in good yield in the presence of an aminoalcohol. Use of a catalytic amount of chiral aminoalcohol led the process to the catalytic asymmetric Aldol-type reaction.
