1443220-96-9Relevant academic research and scientific papers
Stereochemistry of 1,5-benzothiazepin-4-one S-oxide: Insight into the stereogenic elements at the sulfur atom and axis
Tabata, Hidetsugu,Yoneda, Tetsuya,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 6264 - 6270 (2013/07/26)
Oxidation of 1,5-benzothiazepin-4-one (5-A) stereoselectively afforded the S-oxide 8I-A (aS,1S) in preference to the diastereomer 8II-A (aS,1R) affected by the remote stereogenic axis. All the enantiomers (8I-A/8I-B and 8II-A/8II-B) were separated and isolated, and the interconversion between 8I and 8II (equilibrium ratio ≈5:1) was unequivocally verified to be caused by the rotation around the axis.
