1443301-70-9

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 33923-83-0 2-hydroxy-2'-methoxychalcone 
• 75-52-5 nitromethane 
• 1443301-91-4 (E)-ethyl 3-(2-((E)-3-(2-methoxyphenyl)-3-oxoprop-1-en-1-yl)phenoxy)acrylate 
• 90-02-8 salicylaldehyde 

Relevant academic research and scientific papers

Organocatalyzed michael-michael cascade reaction: Asymmetric synthesis of polysubstituted chromans

An enantioselective cascade Michael-Michael reaction between chalcones enolates and nitromethane catalyzed by a bifunctional thiourea is developed. This reaction provides a mild but efficient approach to chiral benzopyrans bearing three consecutive stereocenters in high yields with excellent stereoselectivities, and the benzopyrans can be easily transformed to the corresponding tricyclic product.