1443301-91-4

Upstream product

• 33923-83-0 2-hydroxy-2'-methoxychalcone 
• 623-47-2 propynoic acid ethyl ester 
• 579-74-8 2-Methoxyacetophenone 

Downstream Products

• 1443301-70-9 ethyl 2-((2S,3S,4R)-4-(2-(2-methoxyphenyl)-2-oxoethyl)-3-nitrochroman-2-yl)acetate 

Relevant academic research and scientific papers

Organocatalyzed michael-michael cascade reaction: Asymmetric synthesis of polysubstituted chromans

An enantioselective cascade Michael-Michael reaction between chalcones enolates and nitromethane catalyzed by a bifunctional thiourea is developed. This reaction provides a mild but efficient approach to chiral benzopyrans bearing three consecutive stereocenters in high yields with excellent stereoselectivities, and the benzopyrans can be easily transformed to the corresponding tricyclic product.