1443307-91-2

Basic information

• Product Name: C₃₅H₄₀N₄O₅
• CAS NO: 1443307-91-2
• Molecular Weight: 596.726
• Mol File: 1443307-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₄₀N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₄₀N₄O₅(1443307-91-2)
• EPA Substance Registry System: C₃₅H₄₀N₄O₅(1443307-91-2)

Safety Data

• Hazardous Substances Data: 1443307-91-2(Hazardous Substances Data)

Upstream product

• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 54793-76-9 L-tryptophan-L-leucine methylester 

Relevant articles and documents

Peptides and peptidoaldehydes as substrates for the Pictet-Spengler reaction

The Pictet-Spengler (PS) reaction was performed with various types of substrates: H-Trp-OMe and dipeptides with N-terminal Trp as arylethylamine components and Z-protected amino aldehydes and peptidoaldehydes as carbonyl components. We found that the C-terminal part of Trp derivatives did not have any influence on the stereoselectivity of the reaction and the results are the same for simple esters of Trp and dipeptides. On the contrary, the selectivity of the PS reaction with peptidoaldehydes with L configuration of the C-terminus residue is totally different from that obtained with simple L-amino aldehydes. It allows us to obtain cis stereoisomers, which cannot be isolated from the reaction with amino aldehydes. But the utility of the peptidoaldehydes as substrates for the PS reaction is reduced by the side formation of enamides which decrease the yield of cyclization.