1443534-18-6

Basic information

• Product Name: (2S,3S,4S,5R,6S)-benzyl 6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
• Synonyms: (2S,3S,4S,5R,6S)-benzyl 6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
• CAS NO: 1443534-18-6
• Molecular Weight: 521.949
• Mol File: 1443534-18-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S,4S,5R,6S)-benzyl 6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,4S,5R,6S)-benzyl 6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate(1443534-18-6)
• EPA Substance Registry System: (2S,3S,4S,5R,6S)-benzyl 6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate(1443534-18-6)

Safety Data

• Hazardous Substances Data: 1443534-18-6(Hazardous Substances Data)

Upstream product

• 65178-23-6 4-chlorobenzothio[¹⁴C]amide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 17969-20-9 fenclozic acid 

Downstream Products

• 1443534-19-7 (2S,3S,4S,5R,6S)-6-({2-[2-(4-chlorophenyl)[2-¹⁴C]-1,3-thiazol-4-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid 

Relevant articles and documents

A modern approach to the synthesis of 2-(4-chlorophenyl)[2- 14C]thiazol-4-ylacetic acid ([14C] fenclozic acid) and its acyl glucuronide metabolite

An updated approach to the 1960s synthesis of [14C] fenclozic acid from labelled potassium cyanide is presented. By employing modern synthetic methodology and purification techniques, many of the inherent hazards in the original synthesis are avoided or significantly reduced. The concomitant labelled stereoselective synthesis of the key acyl glucuronide metabolite (the 1-β-O-acyl glucuronide) is also described. [14C]Fenclozic acid and its key acyl glucuronide metabolite, the 1-β-O-acyl glucuronide were prepared from labelled potassium cyanide. [14C]Fenclozic acid had previously been prepared in the 1960s, however in this paper we describe a shorter synthesis that avoids or reduces some of the inherent hazards present in the original synthesis. Copyright