1443538-48-4 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride is used as a key intermediate in the synthesis of tropomyosin receptor kinase A (TrkA) inhibitors. TrkA is a receptor tyrosine kinase involved in various cellular processes, including cell survival, differentiation, and proliferation. Inhibition of TrkA has been explored as a potential therapeutic strategy for the treatment of various cancers, as it can help prevent tumor growth and progression.
The compound's specific structural features make it a valuable building block for the development of novel TrkA inhibitors with improved potency, selectivity, and pharmacokinetic properties. By incorporating (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride into the design of new drugs, researchers can potentially enhance the effectiveness of TrkA-targeted therapies and provide better treatment options for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1443538-48-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,5,3 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1443538-48:
(9*1)+(8*4)+(7*4)+(6*3)+(5*5)+(4*3)+(3*8)+(2*4)+(1*8)=164
164 % 10 = 4
So 1443538-48-4 is a valid CAS Registry Number.
1443538-48-4Relevant academic research and scientific papers
SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
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Paragraph 0561; 0611, (2015/01/06)
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
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Page/Page column 59; 68-69, (2013/07/05)
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors., method of making and pharmaceutical compositions comprising such compounds.
