14436-27-2Relevant academic research and scientific papers
Biosynthesis of Estrogens: Aromatization of (19R)-, (19S)-, and (19RS)--3β-Hydroxyandrost-5-en-17-ones by Human Placental Aromatase
Caspi, Eliahu,Arunachalam, Thangavel,Nelson, Peter A.
, p. 1847 - 1852 (1986)
It is shown, with the use of (19R)- and (19S)--3β-hydroxyandrost-5-en-17-ones, that the "first" C-19 hydroxylation by human placental aromatase involves a normal kinetic isotope effect kH > kD >kT.The hydroxylation proceeds stereospecifically in the retention mode; i.e., the incoming hydroxyl assumes the orientation of the displaced (isotopic) hydrogen atom.
