Journal of the American Chemical Society p. 1847 - 1852 (1986)
Update date:2022-08-03
Topics:
Caspi, Eliahu
Arunachalam, Thangavel
Nelson, Peter A.
It is shown, with the use of (19R)- and (19S)-<19-3H,2H,1H>-3β-hydroxyandrost-5-en-17-ones, that the "first" C-19 hydroxylation by human placental aromatase involves a normal kinetic isotope effect kH > kD >kT.The hydroxylation proceeds stereospecifically in the retention mode; i.e., the incoming hydroxyl assumes the orientation of the displaced (isotopic) hydrogen atom.
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