144366-96-1Relevant academic research and scientific papers
SYNTHETIC ANTIBODY MIMETIC COMPOUNDS (SYAMS) TARGETING CANCER, ESPECIALLY PROSTATE CANCER
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Page/Page column 83, (2014/11/13)
The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a FcγRI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a FcγRI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient. Methods of using these compounds to treat cancer and/or reduce the likelihood of metastatis of cancer are additional aspects of the present invention.
Chemically synthesized molecules with the targeting and effector functions of antibodies
McEnaney, Patrick J.,Fitzgerald, Kelly J.,Zhang, Andrew X.,Douglass, Eugene F.,Shan, Weifang,Balog, Aaron,Kolesnikova, Mariya D.,Spiegel, David A.
, p. 18034 - 18043 (2015/03/13)
This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds-called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)-bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-molecule and biologic therapies, and may address many drawbacks associated with available treatments for cancer and other diseases.
SYNTHESIS OF AZA-CROWN COMPOUNDS BY INTRAMOLECULAR CYCLIZATION OF ω-AMINO ACIDS
Mikhura, I. V.,Formanovskii, A. A.
, p. 205 - 212 (2007/10/02)
A method for the synthesis of aza-crown compounds by the intramolecular cyclization of ω-amino acids with subsequent reduction of the lactam to a macrocyclic amine was developed. 1,8-Diazacyclotetradecane and 1,8-dioxa-4,11-diazacyclotetradecane was synthesized in preparative yields.The structural assignments were made using the IR, 1H and 13C NMR, and mass spectra.
