144375-66-6

Upstream product

• 126378-42-5 4-methoxy-3-(trisopropylsilyl)pyridine 
• 161693-64-7 (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate 
• 126378-43-6 (1R,2S,5R)-(-)-8-phenylmenthyl chloroformate 
• 126378-43-6 (-)-8-phenylmenthol chloroformate 

Downstream Products

• 126378-69-6 (S)-2-Isobutyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-69-6 (R)-2-Isobutyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-63-0 (R)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-63-0 (S)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-62-9 (R)-2-(4-Methoxy-phenyl)-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-62-9 (S)-2-(4-Methoxy-phenyl)-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-60-7 (R)-4-Oxo-2-p-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-60-7 (S)-4-Oxo-2-p-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-71-0 (R)-2-Cyclohexyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-71-0 2(S)-cyclohexyl-1-<((1R,2S,5R)-8-phenylmenthoxy)carbonyl>-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone 
• 154467-62-6 (R)-4-Oxo-2-pent-4-enyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 126378-60-7 2(S)-(4-methylphenyl)-1-<((1R,2S,5R)-8-phenylmenthoxy)carbonyl>-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone 
• 68622-77-5 (-)-Lasubine I 
• 68622-78-6 (+)-subcosine I 

Relevant academic research and scientific papers

Synthesis and reactions of enantiopure 1-acyl-2-[triaryl(alkyl)silyl]-2,3-dihydro-4-pyridones

The addition of triphenylsilyl- or dimethylphenylsilymagnesium bromide to certain chiral 1-acylpyridinium salts affords C-2 silylated dihydro-4-pyridones in good yield and high diastereoselectivity (84 - 96% de). Reduction and substitution reactions of th

The Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts. An Asymmetric Synthesis of (-)-Sedamine

Synthetically useful 2-(2-oxoalkyl)-2,3-dihydro-4-pyridones are prepared in high diastereomeric excess by addition of ketone metallo enolates to chiral 1-acyl-4-methoxypyridinium salts.

Conversion of N-Acyl-2,3-dihydro-4-pyridones to 4-Chloro-1,2-dihydropyridines Using the Vilsmeier Reagent. Synthesis of (-)-Coniine and (+/-)-Lupinine

The full details are given of a study on the conversion of dihydropyridones of the type 3 to 4-chloro-1,2-dihydropyridines 4 using a Vilsmeier reagent.The use of 1 equiv of Vilsmeier reagent under mild conditions (ClCHCCl2, rt) transformed several racemic

Asymmetric Synthesis of 2-Alkyl(Aryl)-2,3-dihydro-4-pyridones by Addition of Grignard Reagents to Chiral 1-Acyl-4-methoxypyridinium Salts

Grignard addition to a chiral 1-acyl-4-methoxypyridinium salt provides synthetically useful 2-alkyl(aryl)-2,3-dihydro-4-pyridones in high diastereomeric excess.