1443753-01-2

Upstream product

• 286434-45-5 2-fluoro-4,6-dimethoxybenzoic acid 
• 75996-29-1 5-fluororesorcinol 
• 52189-63-6 3,5-dimethoxyfluorobenzene 
• 110-87-2 3,4-dihydro-2H-pyran 
• 1443753-00-1 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone 

Downstream Products

• 1443773-61-2 C₃₉H₄₆FNO₇ 
• 1443773-87-2 C₄₀H₅₀FNO₇ 
• 1443752-74-6 5-fluoro-3-(4-hydroxyphenyl)-4-methyl-2-{4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl}-2H-chromen-7-ol 
• 1443753-02-3 C₃₁H₃₁FO₇ 

Relevant academic research and scientific papers

ANTI-ESTROGENIC COMPOUNDS

The present disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt wherein X, R1-R8, Y1-Y5, m, n, p, and q are defined herein. The novel 2H-chromene compounds are useful for the modul

NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP- 1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-l-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin- 1 -yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.