144380-73-4Relevant academic research and scientific papers
A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics
Mitcheltree, Matthew J.,Stevenson, Jack W.,Pisipati, Amarnath,Myers, Andrew G.
, p. 6829 - 6835 (2021)
The development of a flexible, component-based synthetic route to the amino sugar fragment of the lincosamide antibiotics is described. This route hinges on the application and extension of nitroaldol chemistry to forge strategic bonds within complex amino sugar targets and employs a glycal epoxide as a versatile glycosyl donor for the installation of anomeric groups. Through building-block exchange and late-stage functionalization, this route affords access to a host of rationally designed lincosamides otherwise inaccessible by semisynthesis and underpins a platform for the discovery of new lincosamide antibiotics.
LINCONSAMIDE ANTIBIOTICS AND USES THEREOF
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Paragraph 00412, (2019/02/25)
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.
Synthesis of functionalized nitroalkanes by oxidation of oximes with urea-hydrogen peroxide complex and trifluoroacetic anhydride
Ballini, Roberto,Marcantoni, Enrico,Petrini, Marino
, p. 4835 - 4838 (2007/10/02)
Reaction of urea-hydrogen peroxide complex with trifluoroacetic anhydride in acetonitrile at 0°C affords in a safe and easy fashion anhydrous solutions of peroxytrifluoroacetic acid. These can be used to oxidize aldoximes to nitroalkanes in good yields. Ketoximes fail to react in these conditions and are cleaved to the parent carbonyl compounds.
