1444006-16-9

Basic information

• Product Name: 6-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one
• Synonyms: 6-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one
• CAS NO: 1444006-16-9
• Molecular Weight: 383.401
• Mol File: 1444006-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one(1444006-16-9)
• EPA Substance Registry System: 6-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one(1444006-16-9)

Safety Data

• Hazardous Substances Data: 1444006-16-9(Hazardous Substances Data)

Upstream product

• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 27992-32-1 6-bromo-2-pyridone 
• 622864-48-6 (3-hydroxy-4-methoxyphenyl)boronic acid 
• 1444006-14-7 6-bromo-1-(3,4,5-trimethoxyphenyl)pyridin-2(1H)-one 

Relevant articles and documents

Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs

A series of 1,6-diaryl pyridin-2(1H)-one analogs were designed and synthesized via consecutive Chan-Lam coupling and Suzuki coupling. These novel compounds were evaluated for their antiproliferative activity against two tumor cell lines (SKOV-3 and HepG2). Compounds 1b, 1c, 1e and 1f displayed comparable in vitro cytotoxicity with taxol, while their in vivo antitumor activity was less effective than taxol. In addition, cell cycle assay indicated that these 1,6-diaryl pyridin-2(1H)-one compounds induced cell cycle arrest in the G1/M phase in the HepG2 cell line.