144402-30-2

Upstream product

• 144402-29-9 (2S,4S,6R,7S)-8-benzyloxy-1,2-O-diphenylmethylidene-7-methyloctane-1,2,4,6-tetrol 
• 77-76-9 2,2-dimethoxy-propane 
• 144402-27-7 2-<(2S)-2,3-O-(diphenylmethylidene)-2,3-dihydroxypropyl>-1,3-dithiane 
• 144402-41-5 (2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol 
• 144402-28-8 (2S,6R,7S)-8-benzyloxy-1,2-O-diphenylmethylidene-7-methyloctan-4-one-1,2,6-triol 
• 81380-10-1 (2S,3S)-4-benzyloxy-1,2-epoxy-3-methylbutane 

Downstream Products

• 164031-24-7 (S)-2-[(4R,6S)-6-((S)-2,2-Diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-1-ol 
• 144402-31-3 (2S,4S,6R,7S)-8-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-4,6-O-isopropylidene-7-methyloctane-1,2,4,6-tetrol 
• 144402-35-7 (2R,6S,8R,10R,11S)-12-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-8,10-O-isopropylidene-11-methyldodecan-4-one-1,2,6,8,10-pentol 
• 144402-42-6 (S)-1-{(4R,6R)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-[2-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol 
• 144402-39-1 (2R,6S,8R,10R,12R,14R,15S)-16-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-8,10:12,14-bis-O-isopropylidene-15-methylhexadecan-4-one-1,2,6,8,10,12,14-heptol 
• 144402-26-6 (2R,4R,6S,8R,10R,12R,14R,15S)-16-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-4,6:8,10:12,14-tris-O-isopropylidene-15-methylhexadecane-1,2,6,8,10,12,14-octol 
• 144402-44-8 (S)-1-((4S,6R)-6-{(4R,6R)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-3-[2-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol 
• 144402-36-8 (2R,4R,6S,8R,10R,11S)-12-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-8,10-O-isopropylidene-11-methyldodecane-1,2,4,6,8,10-hexol 
• 144402-36-8 (2S,4R)-1-{(4R,6R)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-((R)-2,2-diphenyl-[1,3]dioxolan-4-yl)-pentane-2,4-diol 
• 144402-37-9 tert-Butyl-((S)-2-{(4R,6R)-6-[(4S,6S)-6-((R)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propoxy)-dimethyl-silane 
• 144402-37-9 (2R,4R,6S,8R,10R,11S)-12-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-4,6:8,10-bis-O-isopropylidene-11-methyldodecane-1,2,4,6,8,10-hexol 
• 144402-40-4 (2R,4R,6S,8R,10R,12R,14R,15S)-16-<(tert-butyldimethylsilyl)oxy>-1,2-O-diphenylmethylidene-8,10:12,14-bis-O-isopropylidene-15-methylhexadecane-1,2,6,8,10,12,14-octol 
• 144402-40-4 (2S,4R)-1-((4S,6R)-6-{(4R,6R)-6-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-5-((R)-2,2-diphenyl-[1,3]dioxolan-4-yl)-pentane-2,4-diol 

Relevant academic research and scientific papers

Total synthesis of the polyene macrolide antibiotic roxaticin. I. Synthesis of the polyol fragment of roxaticin using a four-carbon chain extension strategy

The C11-C26 polyol fragment of roxaticin containing eight chiral centers has been prepared in a reiterative manner using coupling reactions of chiral dithianes and epoxides followed by stereoselective reduction.

SYNTHESIS OF EXTENDED 1,3-POLYOLS USING FOUR-CARBON UNITS: AN APPROACH TO THE CONSTRUCTION OF THE POLYOL FRAGMENT OF ROXATICIN

The polyol fragment of roxaticin containing eight chiral centers has been prepared in a reiterative manner using coupling reactions of chiral dithianes with epoxides followed by stereoselective reduction.