144429-71-0 Usage
Uses
Used in Pharmaceutical Industry:
Goniodiol 8-acetate is used as a potential therapeutic agent for its anti-inflammatory and analgesic effects. It is being explored for its potential to alleviate pain and reduce inflammation, which are common symptoms in various medical conditions.
Used in Neurological Applications:
Goniodiol 8-acetate is used as a potential treatment for neurological disorders due to its interaction with the endocannabinoid system. This system plays a crucial role in maintaining homeostasis in the central and peripheral nervous systems, and modulation of this system may provide therapeutic benefits for conditions such as multiple sclerosis, neuropathic pain, and epilepsy.
Used in Dermatological Applications:
Goniodiol 8-acetate is used as a potential treatment for skin conditions characterized by inflammation and pain, such as psoriasis and eczema. Its anti-inflammatory and analgesic properties may help alleviate symptoms and improve skin health.
Used in Pain Management:
Goniodiol 8-acetate is used as an analgesic agent for the management of chronic and acute pain. Its potential to interact with the endocannabinoid system may provide a novel approach to pain relief, offering an alternative to traditional pain medications.
Used in Research and Development:
Goniodiol 8-acetate is used as a subject of research for further exploration of its pharmacological properties and potential medical uses. Ongoing studies aim to understand its mechanisms of action, efficacy, and safety profile, which will inform future therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 144429-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,2 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 144429-71:
(8*1)+(7*4)+(6*4)+(5*4)+(4*2)+(3*9)+(2*7)+(1*1)=130
130 % 10 = 0
So 144429-71-0 is a valid CAS Registry Number.
144429-71-0Relevant articles and documents
A short and general approach to the synthesis of styryllactones: (+)-Goniodiol, its acetates and β-trifluoromethyl derivative, (+)-7-epi-Goniodiol and (+)-9-deoxygoniopypyrone
Chen, Jian,Lin, Guo-Qiang,Wang, Zhi-Min,Liu, Han-Quan
, p. 1265 - 1268 (2007/10/03)
(+)-Goniodiol, its acetates and β-trifluoromethyl derivative, (+)-7-epi-Goniodiol and (+)-9-deoxygoniopypyrone, the representatives of styryllactones have been synthesized in a short and general way. The key steps involve the regioselective asymmetric dihydroxylation and the palladium-catalyzed cross-coupling of cyclic allylic carbonate with vinyltributylstannane.
Enantioselective synthesis of (+)-goniodiol and of its naturally occurring acetylated analogs
Surivet, Jean-Philippe,Gore, Jacques,Vatele, Jean-Michel
, p. 14877 - 14890 (2007/10/03)
A novel route to enantioenriched (+)-goniodiol and its natural acetylated derivatives, potent cytotoxic compounds, is described. The main features of this synthesis are transfer of the asymmetric information of the scalemic allenic alcohol 5 to the α- and β- carbons through highly diastercoselective reactions and introduction of the α,β-unsaturated lactone moiety by the Ghosez' methodology.
Total synthesis of the natural goniodiol-8-monoacetate from cinnamyl alcohol
Yang,Zhou
, p. 743 - 744 (2007/10/02)
The first total synthesis of goniodiol-8-monoacetate, using the Sharpless asymmetric epoxidation starting from cinnamyl alcohol in twelve steps with an overall yield of 7%, is achieved.
