162600-00-2Relevant academic research and scientific papers
Total synthesis and cytotoxicity of (+)- and (-)-goniodiol and 6-epi-goniodiol. Construction of α,β-unsaturated lactones by ring-closing metathesis
Nakashima, Katsuyuki,Kikuchi, Naoki,Shirayama, Daisuke,Miki, Takuo,Ando, Kazuhiro,Sono, Masakazu,Suzuki, Shinya,Kawase, Masaki,Kondoh, Masuo,Sato, Masao,Tori, Motoo
, p. 387 - 394 (2008/02/11)
(+)-Goniodiol, a potent and selective cytotoxin, and (-)-6-epi-goniodiol, as well as their enantiomers, have been synthesized starting from cinnamyl alcohol. The key steps of the synthesis were Sharpless asymmetric epoxidation and cyclization of an acrylate derivative using ring-closing metathesis reaction. The cytotoxicity of both enantiomers of goniodiol and 6-epi-goniodiol against HL-60 cells was examined.
NOREPINEPHRINE TRANSPORTER RADIOTRACERS AND METHODS OF SYNTHESES THEREOF
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Page/Page column 45, (2008/06/13)
The present invention provides compounds and radiotracers thereof for locating, diagnosing, identifying, evaluating, detecting or quantitating NET by in vivo imaging. The invention also provides methods for locating, diagnosing, identifying, evaluating, detecting or quantitating NET, using radiotracers of high-affinity or labeled compounds of the invention, which exhibit low toxicity, can cross the blood-brain barrier and, preferably, distinguish among normal and abnormal brains. For example, a radiotracer of the invention can be administered to a patient in an amount suitable for in vivo imaging thereof. Preferably, radiotracers of the invention can also be used to locate, diagnosis, identify, evaluate, detect and quantitate NET in such diseases, disorders, conditions or maladies as, without limitation, depression, anxiety, ADHD and drug dependency.
A total synthesis of the styryllactone (+)-goniodiol from naphthalene
Banwell, Martin G.,Coster, Mark J.,Edwards, Alison J.,Karunaratne, Ochitha P.,Smith, Jason A.,Welling, Lee L.,Willis, Anthony C.
, p. 585 - 595 (2007/10/03)
The cytotoxic natural product (+)-goniodiol (1) has been prepared in twelve steps from the enantiomerically pure cis-dihydrocatechol (2), which is readily obtained by microbial oxidation of naphthalene. Elaboration of compound (2) involves an initial oxid
A chemoenzymatic synthesis of the styryllactone (+)-goniodiol from naphthalene
Banwell, Martin G.,Coster, Mark J.,Karunaratne, Ochitha P.,Smith, Jason A.
, p. 1622 - 1624 (2007/10/03)
The enantiomerically pure cis-1,2-diol 2, which is obtained by microbial oxidation of naphthalene, has been converted, via a sequence of reactions including oxidative C-C bond cleavage, decarbonylation and ring-closing metathesis steps, into the natural p
Asymmetric Total Synthesis of (+)-Goniotriol and (+)-Goniofufurone
Yang, Zhi-cai,Zhou, Wei-shan
, p. 1429 - 1436 (2007/10/02)
Thr Enantioselective synthesis of two antitumor styryl lactones, (+)-goniotriol and (+)-goniofufurone, have been completed starting from cinnamyl alcohol in ten and eleven steps with an overall yield of 21percent and 12percent, respectively.
Total synthesis of the natural goniodiol-8-monoacetate from cinnamyl alcohol
Yang,Zhou
, p. 743 - 744 (2007/10/02)
The first total synthesis of goniodiol-8-monoacetate, using the Sharpless asymmetric epoxidation starting from cinnamyl alcohol in twelve steps with an overall yield of 7%, is achieved.
