144456-56-4

Basic information

• Product Name: 10H-Phenothiazine-10-propanamide, 2-chloro-N-methyl-N-phenyl-
• CAS NO: 144456-56-4
• Molecular Formula: C22H19ClN2OS
• Molecular Weight: 394.925
• Mol File: 144456-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 10H-Phenothiazine-10-propanamide, 2-chloro-N-methyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 10H-Phenothiazine-10-propanamide, 2-chloro-N-methyl-N-phenyl-(144456-56-4)
• EPA Substance Registry System: 10H-Phenothiazine-10-propanamide, 2-chloro-N-methyl-N-phenyl-(144456-56-4)

Safety Data

• Hazardous Substances Data: 144456-56-4(Hazardous Substances Data)

Upstream product

• 92-39-7 2-chlorophenothiazine 
• 4414-83-9 3-(2-chloro-10H-phenothiazin-10-yl)propanonitrile 
• 87108-84-7 2-chloro-10H-phenothiazine-10-propionyl chloride 
• 100-61-8 N-methylaniline 

Relevant articles and documents

Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C

In order to study the structure-activity relationships of phenothiazine derivatives inhibiting phosphatidylinositol-specific phospholipase C (PI-PLC), the synthesis of some phenothiazine amide, amine and ester derivatives was performed mainly by reacting 10H-phenothiazine-10-propanoyl chloride with some amines and alcohols; the resulting amides were reduced with borane to yield the corresponding amines. Starting from 2-chloro and 2-trifuoromethyl-10H-phenothiazine-10-propanoyl chloride two amides were synthesized. The inhibiting activity on PI-PLC from human platelets is reported.