4414-83-9

Basic information

• Product Name: 2-Chloro-10H-phenothiazine-10-propanenitrile
• Synonyms: 2-Chloro-10H-phenothiazine-10-propanenitrile;3-(2-chloro-10H-phenothiazin-10-yl)propanenitrile
• CAS NO: 4414-83-9
• Molecular Formula: C₁₅H₁₁ClN₂S
• Molecular Weight: 286.78
• Mol File: 4414-83-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 490°C at 760 mmHg
• Flash Point: 250.2°C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 9.47E-10mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2-Chloro-10H-phenothiazine-10-propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-10H-phenothiazine-10-propanenitrile(4414-83-9)
• EPA Substance Registry System: 2-Chloro-10H-phenothiazine-10-propanenitrile(4414-83-9)

Safety Data

• Hazardous Substances Data: 4414-83-9(Hazardous Substances Data)

Usage

Uses

2-Chloro-10-phenothiazinepropionitrile is an intermediate in the synthesis of Didesmethylchlorpromazine Hydrochloride (D440905), an impurity of Chlorpromazine (C424750) which has antiemetic; antipsychotic properties.

InChI:InChI=1/C15H11ClN2S/c16-11-6-7-15-13(10-11)18(9-3-8-17)12-4-1-2-5-14(12)19-15/h1-2,4-7,10H,3,9H2

Upstream product

• 101-17-7 3-chlorodiphenylamine 
• 92-39-7 2-chlorophenothiazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 1225-64-5 Norchlorpromazine 
• 144456-56-4 3-(2-Chloro-phenothiazin-10-yl)-N-methyl-N-phenyl-propionamide 
• 2095-17-2 2-chloro-10-(3-aminopropyl)phenothiazine 
• 50-53-3 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 
• 84-01-5 chlorproethazine 

Relevant articles and documents

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study.

Synthesis of nor1- and nor2-chlorpromazine derivatives.

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