14446-73-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Cyclohexylpiperidine (SALTDATA: FREE) is used as a reactant for the preparation (N-alkylation) of aminoalkyl naphtholactams and naphthosultams. These compounds serve as serotoninergic 5-HT7 receptor antagonists, which have potential applications in the treatment of various neurological and psychiatric disorders, such as depression, anxiety, and schizophrenia. The 5-HT7 receptor antagonists modulate the serotonin signaling pathway, which is involved in the regulation of mood, sleep, and other cognitive functions.

Upstream product

• 89656-54-2 tert-Butyl-[1-(4-cyclohexyl-3,4-dihydro-2H-pyridin-1-yl)-meth-(E)-ylidene]-amine 
• 939-23-1 p-phenylpyridine 
• 89656-23-5 1,2,5,6-tetrahydropyridine N'-tert-butylformamidine 
• 16663-69-7 4-phenylpyridine hydrochloride 
• 771-99-3 4-phenylpiperidine 

Downstream Products

• 33024-15-6 3-(4-cyclohexyl-piperidin-1-yl)-rifamycin 
• 63757-21-1 1-(4-cyclohexylpiperidino)pentan-4-one 
• 1194373-03-9 4-cyclohexyl-1-[2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yloxy)ethyl]piperidine 
• 1194372-90-1 4-cyclohexyl-1-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl-propyl)]piperidine 
• 1194373-04-0 N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(4-cyclohexylpiperidine)acetamide 
• 1194372-89-8 4-cyclohexyl-1-[5-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylpentyl)]piperidine 
• 1269606-79-2 2-(4-Cyclohexyl-piperidin-1-yl)-1-phenyl-ethanol 
• 1269606-10-1 1-[2-(4-Cyclohexyl-piperidin-1-yl)-1-phenyl-ethyl]-4-(2-methoxy-ethyl)-piperazine 
• 1533426-12-8 3-[4-(4-cyclohexyl-1-piperidino)butyl]-1H-indole 
• 1533426-19-5 9-[4-(4-cyclohexyl-1-piperidino)butyl]-9H-carbazole 
• 1533426-09-3 3-[4-(4-cyclohexyl-1-piperidino)butyl]-1-(4-fluorophenyl)-1H-indole 
• 1450648-80-2 N-(4-methylphenyl)-4-[(4-cyclohexyl-1-piperidinyl)carbonyl]-1,3-thiazol-2-amine 
• 1400928-30-4 C₂₅H₃₇N₃O₂ 

Relevant academic research and scientific papers

Novel Ethanediamone Hepcidine Antagonists

The present invention relates to novel hepcidin antagonists of formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for treatment of disorders in iron metabolism, such as, in particular, iron deficiency diseases and anaemias, in particular anaemias in connection with chronic inflammatory diseases (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

Benzimidazolidinone derivatives as muscarinic agents

Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture

The present invention relates to carboxamide compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1, R2, R3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Identification of a non peptidic RANTES antagonist

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50 = 3 μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.

Acyl derivatives of rifamycins and their use as medicaments

The invention relates to novel polycyclic derivatives of rifamycins of the formula and the salts thereof, in which the structural elements -A1-A2-, -A3-A4- and -A5-A6- each denote ethylene

3-(Piperidino-lower-alkyl)-indoles

1-Acyl-3-(amino-lower-alkyl)indoles, useful as anti-inflammatory agents, are prepared either by acylation of a 3-(amino-lower-alkyl)indole; by Fisher indole synthesis from an N'-acylphenylhydrazine and an amino-lower-alkanone; by alkylation of an amine with a 1-acyl-3-(halo-lower-alkyl)indole; or by reductive alkylation of a 1-acyl-3-indole-lower-alkylcarboxaldehyde.

Phenyl-lower-alkylamines

Phenyl-lower-alkylamines having anti-inflammatory activity are prepared either by reductive alkylation of an amine with a phenyl-lower-alkanaldehyde; by condensation of a phenyl-lower-alkanaldehyde with a secondary amine, conversion of the resulting phenylvinylamine to the corresponding iminium salt, and reduction of the latter with an alkali metal borohydride; or by reaction of a phenyl-lower-alkanoyl halide with an amine and reduction of the resulting amide with a reagent effective to reduce an amide to an amine.