153109-93-4

Upstream product

• 540-63-6 ethane-1,2-dithiol 
• 1026460-58-1 (2R,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-formyl-3-methoxymethoxy-piperidine-1-carboxylic acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 144463-13-8 Dimethyl (-)-3-acetoxy-6-<2-(tert-butyldiphenylsilyloxy)ethyl>piperidine-1,2-dicarboxylate 
• 194228-04-1 Dimethyl (-)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate 
• 1054636-05-3 (2R,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-hydroxy-piperidine-1,2-dicarboxylic acid dimethyl ester 
• 144463-07-0 Methyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-2-hydroxymethyl-3-(methoxymethoxy)piperidine-1-carboxylate 
• 144463-12-7 (2R,3S,6S)-3-Acetoxy-6-(2-hydroxy-ethyl)-piperidine-1,2-dicarboxylic acid dimethyl ester 

Downstream Products

• 194228-05-2 (2S,3S,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-methoxymethoxy-2-methyl-piperidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Bicyclo[3.3.1]nonanes as synthetic intermediates. Part 21. Enantiodivergent synthesis of the cis,cis 2,6-disubstituted piperidin-3-ol chiral building block for alkaloid synthesis

Enantiodivergent synthesis of the enantio-pure cis,cis 3-protected 2,6-disubstituted piperidin-3-ol 1 has been achieved via a biochemical method, and the absolute stereochemistry of (+)-1 has been established by its conversion into the known piperidine (-

Asymmetric synthesis of the alkaloid 2,6-disubstituted piperidin-3-ols, (-)-cassine and (+)-spectaline

The asymmetric total synthesis of (-)-cassine (1) and (+)-spectaline (2) was achieved by starting with both enantiomers of the homochiral 3-oxygenated 2,6-cis-disubstituted piperidine 3.