144464-54-0

Basic information

• Product Name: 2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE
• Synonyms: 2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE
• CAS NO: 144464-54-0
• Molecular Formula: C₂₁H₁₆N₂O
• Molecular Weight: 312.36
• Mol File: 144464-54-0.mol
• Article Data: 53

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE(144464-54-0)
• EPA Substance Registry System: 2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE(144464-54-0)

Safety Data

• Hazardous Substances Data: 144464-54-0(Hazardous Substances Data)

Usage

Chemical compound

2-AMINO-4-(4-METHYLPHENYL)-4H-BENZO[H]CHROMENE-3-CARBONITRILE

Class

Benzo[h]chromene derivatives

Structure

Benzo[h]chromene core substituted with an amino group, a 4-methylphenyl group, and a carbonitrile group at the 3-position

Biological activities

Potential biological activities

Application

Medicinal chemistry and drug discovery research

Value

Valuable scaffold for the development of novel pharmaceutical compounds

Therapeutic applications

Particularly in the treatment of cancer, inflammation, and neurological disorders

Upstream product

• 90-15-3 α-naphthol 
• 2826-25-7 2-(4-methylbenzylidene)malononitrile 
• 589-18-4 4-Methylbenzyl alcohol 
• 109-77-3 malononitrile 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 144464-58-4 8-Amino-10-methyl-7-p-tolyl-7H-12-oxa-11-aza-benzo[a]anthracene-9-carbonitrile 
• 1259371-49-7 10-methyl-7-(4-methylphenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene-8-one 
• 1393816-51-7 7-(p-tolyl)-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amine 
• 1613306-52-7 methyl 2-cyano-3-(4-methylphenyl)-2,3-dihydronaphtho[1,2-b]furan-2-carbimidate 
• 1613306-66-3 dimethyl 3-(4-methylphenyl)naphtho[1,2-b]furan-2,2(3H)-bis(carbimidate) 
• 1414397-81-1 C₂₂H₁₉ClN₂O₂ 
• 1621314-74-6 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one 
• 1621314-58-6 2-chloro-N-(3-cyano-4-(p-methylphenyl)-4H-benzo[h]chromen-2-yl)acetamide 
• 1446242-91-6 2-oxo-4-p-tolyl-2H-benzo[h]chromene-3-carbonitrile 

Relevant articles and documents

Solvent Selective Polyacrylonitrile Fiber as a Recyclable Catalyst for the Knoevenagel-Michael Reaction in Water

Heterogeneous catalysis is an important branch of sustainable chemistry. In this work, a series of polyacrylonitrile fiber (PANF) fiber catalysts (PANF-E, PANF-EDs, and PANF-D) with different catalytic micro-environments are developed and characterized by

Bipyridinium chloride supported rice husk silica: An efficient nanocomposite for the one-pot preparation of spirooxindole pyran and 2-amino-4h-chromene derivatives

In this paper, rice-husk-silica supported n-propyl bipyridinium chloride (RHPrBPCl) has been prepared as a heterogeneous catalyst. RHPrBPCl has been successfully applied in the one-pot preparation of spirooxindole pyran and 2-amino- 4H-chromene derivative

One-pot Synthesis of 2-Amino-4H-Chromenes using Chicken Eggshell Waste as Green Catalyst under Solvent-Free Conditions

Chicken eggshell waste has been employed as green and efficient catalyst for the preparation of 2-amino-4H-chromenes. The aromatic aldehydes were condensed with malononitrile and 1-naphthol or 2-naphthol under solvent-free condition in the presence of chi