144464-75-5Relevant academic research and scientific papers
Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand
Grassi, David,Li, Hailing,Alexakis, Alexandre
, p. 11404 - 11406 (2013/01/15)
A valuable Cu-free protocol is reported where an NHC ligand has been employed to form quaternary carbon centers bearing fluoroalkyl units. The results obtained, from this allylic substitution, are better in terms of enantioselectivity and regioselectivity compared to the copper catalyzed system.
Remarkable reversal of stereoselectivity in Wittig-type olefinations of α-fluorinated alkyl aryl ketones
Eguchi,Aoyama,Kakinuma
, p. 5545 - 5546 (2007/10/02)
Remarkable reactivity and reversal of stereoselectivity in the Wittig-type olefinations of α-fluorinated alkyl aryl ketones were described. Stabilized Wittig and Horner-Emmons reagents with these ketones selectively afforded the olefinic products in the stereochemically opposite fashion to the non-fluorinated ketone cases. The Still's reagent further reversed the stereochemical outcome with the fluorinated ketones.
