144467-12-9

Basic information

• Product Name: 4-oxo-1,2-diphenyl-pentane carbonitrile
• Synonyms: 4-oxo-1,2-diphenyl-pentane carbonitrile
• CAS NO: 144467-12-9
• Molecular Weight: 263.339
• Mol File: 144467-12-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-oxo-1,2-diphenyl-pentane carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-1,2-diphenyl-pentane carbonitrile(144467-12-9)
• EPA Substance Registry System: 4-oxo-1,2-diphenyl-pentane carbonitrile(144467-12-9)

Safety Data

• Hazardous Substances Data: 144467-12-9(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 1896-62-4 (E)-benzalacetone 
• 6393-50-6 α-lithiophenylacetonitrile 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 60-29-7 diethyl ether 
• 124-41-4 sodium methylate 
• 63064-12-0 3-hydroxy-2,5-diphenyl-3-methylpent-4-enenitrile 

Downstream Products

• 26735-62-6 (2S,3R)-5-Oxo-2,3-diphenyl-hexanoic acid amide 
• 80575-29-7 hydroxy-4 diphenyl-1,2 pentane carbonitrile 
• 26735-65-9 acide oxo-5 diphenyl-2,3 hexanoique (2R*,3R*) 
• 26735-65-9 acide oxo-5 diphenyl-2,3 hexanoique (2R*,3S*) 
• 80575-29-7 hydroxy-4 diphenyl-1,2 pentane carbonitrile (1R*,2R*,4R*) 
• 110032-33-2 2-methyl-4,5-diphenyl-piperidine 
• 67446-00-8 sel de sodium de l'acide hydroxy-5 diphenyl-2,3 hexanoique (2R*,3R*,5R*) 
• 67445-99-2 sel de sodium de l'acide oxo-5 diphenyl-2,3 hexanoique (2R*,3R*) 
• 26735-66-0 methyl-6 diphenyl 3,4 tetrahydro 3,4,5,6 pyrone-2 (3R*,4R*,6R*) 
• 67446-00-8 sel de sodium de l'acide hydroxy-5 diphenyl-2,3 hexanoique (2R*,3S*,5R*) 
• 67445-99-2 sel de sodium de l'acide oxo-5 diphenyl-2,3 hexanoique (2R*,3S*) 
• 26735-66-0 methyl-6 diphenyl-3,4 tetrahydro-3,4,5,6 pyrone-2 (3R*,4S*,6R*) 
• 26735-66-0 methyl-6 diphenyl-3,4 tetrahydro-3,4,5,6 pyrone-2 

Relevant articles and documents

Access to 2-Amino-3-Arylthiophenes by Base-Catalyzed Redox Condensation Reaction Between Arylacetonitriles, Chalcones, and Elemental Sulfur

A straightforward access to 2-amino-3-arylthiophenes has been developed via one-pot two-step three-component reaction of arylacetonitriles, chalcones and elemental sulfur. The first step consists of a DBU-catalyzed formation of Michael adduct between aryl

Reaction of metalated nitriles with enones

(Chemical Equation Presented) There have been a number of reports of the kinetic conjugate (1,4) addition of metalated arylacetonitriles to enones. Several proposals have been made to explain this behavior based on nucleophile structure or aggregation state or on the HSAB properties of the reactants. A reexamination of these studies showed that in each case the 1,4 adducts resulted from equilibration of the kinetically formed 1,2 adducts to the more stable 1,4 adducts. Thus, no conclusions about the origins of 1,4 selectivity can be drawn from these experiments. The 1,2 addition, retro-1,2 addition, 1,4 addition, and retro-1,4 addition of lithiophenylacetonitrile to benzylideneacetone were examined, and a free energy level diagram was constructed for the reaction.

Effect of aggregation of nitrile anions on the 1,2 versus 1,4 regioselectivity towards benzylideneacetone

A direct evidence of the influence of aggregation state of lithiated penylacetonitrile 1 on the 1,2 versus 1,4 regioselectivity towards benzylideneacetone 2 was established. Progressive addition of hexane to THF solutions raised the aggregates proportion of 1 as evidenced by IR ν(CN) band and led to an increase of 1,4 adduct. Monomers afforded 1,2 addition in pure THF.