144474-37-3Relevant articles and documents
Synthesis of potential inhibitors of the glycosphingolipid biosynthesis
Brenner-Weiss, Gerald,Giannis, Athanassios,Sandhoff, Konrad
, p. 5855 - 5860 (1992)
A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diastereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium salt 7. Compound 6 is a powerful inhibitor of the glycosphingolipid biosynthesis.