Tetrahedron p. 5855 - 5860 (1992)
Update date:2022-08-04
Topics:
Brenner-Weiss, Gerald
Giannis, Athanassios
Sandhoff, Konrad
A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diastereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium salt 7. Compound 6 is a powerful inhibitor of the glycosphingolipid biosynthesis.
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(1994)
