144479-41-4

Upstream product

• 136918-14-4 phthalimide 
• 114370-75-1 5-Chloromethyl-1-(4-nitro-phenyl)-1H-[1,2,4]triazole 
• 100-16-3 4-nitrophenylhydrazone 
• 144479-33-4 2-Chloro-N-[(4-nitro-phenyl)-hydrazonomethyl]-acetamide 

Downstream Products

• 144479-47-0 5-aminomethyl-1-(4-nitrophenyl)-1,2,4-triazole 

Relevant academic research and scientific papers

Efficient syntheses of ω-chloro-, ω-imido- and ω-aminoalkyl-1,2,4-triazoles from N-acyl-formamidinium salts or N-acylformamides and hydrazines

ω-Halo and ω-amidoalkylcyanides 1 are transformed to ω-functionalized N-acylformamidinium salts 4 or formamide 6a by HCl catalyzed addition of chloromethylene iminium salts, derived from formamides 2 and POCl3. Advantageously, β-halo-propionyl-