144501-27-9

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 129360-98-1 (E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 152770-18-8 (E,3S,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 152770-17-7 (E,3R,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 152770-16-6 (E,3S,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 129360-69-6 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol 
• 129360-77-6 (E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid (S)-1,1,2-triphenylethyl ester 
• 152770-14-4 (E,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 129360-78-7 (E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid, methyl ester 
• 129359-41-7 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester 
• 129360-72-1 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal 
• 129360-64-1 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole 

Relevant academic research and scientific papers

Inhibitors of cholesterol biosynthesis. 1. 3,5-dihydroxy-7-(N-imidazolyl)- 6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors

3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classes of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that of l

Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents

Compounds of formula STR1 wherein R1 or R2 represents a C1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by o