1445103-79-6Relevant articles and documents
Fluorescence amplified detection of proteases by the catalytic activation of a semisynthetic sensor
Shih, Po-Ming,Liu, Tao-Kai,Tan, Kui-Thong
supporting information, p. 6212 - 6214 (2013/07/26)
A general approach to mimic the sensing scheme of allosteric enzymes is developed. Through the covalent labeling of a sulfonamide inhibitor to the enzyme HCAII via SNAP-tag protein, the enzyme is rendered inactive. Catalytic activation is triggered only when a protease is present to cleave the recognized peptide sequence. The Royal Society of Chemistry 2013.