144514-15-8

Basic information

• Product Name: Carbamodithioic acid, (3,4-difluorophenyl)-, compd. with N,N-diethylethanamine (1:1)
• Synonyms: triethylammonium 3,4-difluorophenyldithiocarbamate
• CAS NO: 144514-15-8
• Molecular Formula: C7H5F2NS2.C6H15N
• Molecular Weight: 306.444
• Mol File: 144514-15-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamodithioic acid, (3,4-difluorophenyl)-, compd. with N,N-diethylethanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamodithioic acid, (3,4-difluorophenyl)-, compd. with N,N-diethylethanamine (1:1)(144514-15-8)
• EPA Substance Registry System: Carbamodithioic acid, (3,4-difluorophenyl)-, compd. with N,N-diethylethanamine (1:1)(144514-15-8)

Safety Data

• Hazardous Substances Data: 144514-15-8(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 121-44-8 triethylamine 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 150454-48-1 sodium salt of diethyl 3,4-difluorophenylamino(mercapto)methylenemalonate 
• 150454-50-5 diethyl 3,4-difluorophenylamino(p-methoxybenzylthio)methylenemalonate 
• 87238-78-6 ethyl 6,7-difluoro-4-hydroxy-2-(p-methoxybenzylthio)quinoline-3-carboxylate 
• 84339-10-6 7-fluoro-1-methyl-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid 
• 84339-08-2 7-fluoro-1-methyl-5-oxo-8-(1-piperazinyl)-5H-thiazolo<3,2-a>quinoline-4-carboxylic acid 
• 113046-60-9 1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 123447-62-1 prulifloxacin 
• 113028-65-2 6-Fluoro-1-(2-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 113046-68-7 6-Fluoro-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 113045-94-6 ethyl 6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1-phenyl-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113045-95-7 ethyl 6-fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylate 
• 113046-49-4 6-Fluoro-4-oxo-1-phenyl-7-(1-piperazinyl)-4H-[1,3]-thiazeto-[3,2-a]quinoline-3-carboxylic acid 
• 144514-24-9 1-(2,4-Difluoro-phenyl)-6,7-difluoro-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 
• 144514-23-8 6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-4H-2-thia-8b-aza-cyclobuta[a]naphthalene-3-carboxylic acid ethyl ester 

Relevant articles and documents

STUDIES ON PYRIDONECARBOXYLIC ACIDS. 1. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF 7-SUBSTITUTED-6-HALO-4-OXO-4H-THIAZETOQUINOLINE-3-CARBOXYLIC ACIDS

A series of thiazetoquinoline-3-carboxylic acids and their esters were prepared and evaluated for antibacterial activity.The derivatives with a hydrogen or methyl group at C-1, fluorine at C-6, and piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity.Compound 29a (NM394) showed excellent in vitro antibacterial activity and low toxicity but poor absorption from the gastrointestinal tract.Compound 29ee (NM441), an N- derivative of 29a, was found to possess a favorable pharmacokinetic profile and oral activity superior to that of ciprofloxacin in experimental animals.

PROCESS FOR THE PREPARATION OF HIGHLY PURE PRULIFLOXACIN

The present invention provides an industrially advantageous process for the preparation of highly pure prulifloxacin of formula I and its pharmaceutically acceptable salts. The present i innvention a also provides a novel process for the purification of prulifloxacin acid addition salt.