144538-22-7

Basic information

• Product Name: (5S,6R)-5,6-Diphenyl-2-morpholinone
• Synonyms: (5S,6R)-5,6-Diphenyl-2-morpholinone;(5S,6R)-2,3,5,6-tetrahydro-5,6- diphenyl-1,4-oxazin;5S,6R-Diphenyl-2-morpholinone;(5S,6R)-5,6-DiphenylMorpholin-2-one;(5S,6R)-Diphenyl-2-morpholinone,99%e.e.
• CAS NO: 144538-22-7
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Product Categories: Heterocycles;Chiral Reagents
• Mol File: 144538-22-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 444°C
• Flash Point: 222.348 °C
• Appearance: /Solid
• Density: 1.159
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 5.68±0.60(Predicted)
• CAS DataBase Reference: (5S,6R)-5,6-Diphenyl-2-morpholinone(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6R)-5,6-Diphenyl-2-morpholinone(144538-22-7)
• EPA Substance Registry System: (5S,6R)-5,6-Diphenyl-2-morpholinone(144538-22-7)

Safety Data

• Hazardous Substances Data: 144538-22-7(Hazardous Substances Data)

Usage

Uses

(5S,6R)-5,6-Diphenyl-2-morpholinone is an intermediate used in the synthesis of (+)- and (-)-spirotryprostatin B via stereoselective 1,3-dipolar cycloaddition

InChI:InChI=1/C16H15NO2/c18-14-11-17-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-10,15-17H,11H2/t15-,16+/m0/s1

Upstream product

• 112741-49-8 tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate 

Downstream Products

• 144436-73-7 (2S,5R,6S,8R,9R)-5,6-diphenyl-7(R)-2'-furyl-8,9-dicarbomethoxy-1-aza-4-oxabicyclo<4.3.0>nonan-3-one 
• 897365-80-9 (2'S,3'R,4'R,5'S)-6-Chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-1'-((1S,2R)-2-hydroxy-1,2-diphenyl-ethyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 
• 282735-73-3 (3R,3'R,4'S,6'R,8'S,8'aS)-1,2,3',4',8',8a'-hexahydro-6'-(2-methoxy-2-methylpropyl)-1',2-dioxo-3',4'-diphenylspiro[3H-indole-3,7'(6'H)-[1H]pyrrolo[2,1-c][1,4]oxazine]-8'-carboxylic acid ethyl ester 
• 214628-38-3 (5S,6R)-4-Oxy-5,6-diphenyl-5,6-dihydro-[1,4]oxazin-2-one 
• 144538-23-8 (2S,5R,6S,8R,9R)-5,6-diphenyl-7(S)-ethyl-8,9-dicarbomethoxy-1-aza-4-oxabicyclo<4.3.0>nonan-3-one 
• 144436-67-9 (2S,5R,6S,8R,9R)-5,6-diphenyl-8,9-dicarbomethoxy-1-aza-4-oxabicyclo<4.3.0>nonan-3-one 

Relevant articles and documents

Asymmetric, stereocontrolled total synthesis of (+) and (-)-spirotryprostatin B via a diastereoselective azomethine ylide [1,3]-dipolar cycloaddition reaction

The asymmetric, stereocontrolled total syntheses of (+) and (-)-spirotryprostatin B (2) are described. Formation of the core pyrrolidine ring was accomplished via a diastereoselective asymmetric [1,3]-dipolar cycloaddition reaction. Addition of 3-methoxy-