897365-80-9Relevant articles and documents
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ding, Ke,Lu, Yipin,Nikolovska-Coleska, Zaneta,Wang, Guoping,Qiu, Su,Shangary, Sanjeev,Gao, Wei,Qin, Dongguang,Stuckey, Jeanne,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng
, p. 3432 - 3435 (2007/10/03)
Potent, specific, non-peptide small-molecule inhibitors of the MDM2-p53 interaction were successfully designed. The most potent inhibitor (MI-63) has a Ki value of 3 nM binding to MDM2 and greater than 10 000-fold selectivity over Bcl-2/Bcl-xL