144543-36-2Relevant academic research and scientific papers
Mild organocatalytic α-methylenation of aldehydes
Erkkil?, Anniina,Pihko, Petri M.
, p. 2538 - 2541 (2006)
A rapid and extremely convenient method for α-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and chemoselectivity.
Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols
Burde, Ameya S.,Karyakarte, Shuklendu D.,Sylvester, Eric D.,Chemler, Sherry R.
supporting information, p. 105 - 108 (2021/01/14)
Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes
Manganese(III) acetate mediated oxidative radical cyclizations. Toward vicinal all-carbon quaternary stereocenters
Logan, Angus W.J.,Parker, Jeremy S.,Hallside, Michal S.,Burton, Jonathan W.
supporting information; experimental part, p. 2940 - 2943 (2012/08/28)
Manganese(III) acetate mediated oxidative radical cyclizations have been used to synthesize a range of densely functionalized and sterically congested cyclopentane-lactones. A number of the resulting lactones contain vicinal all-carbon quaternary stereocenters adjacent to a tertiary benzylic stereocenter and are formed with high levels of stereocontrol.
Efficient, direct α-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate
Bugarin, Alejandro,Jones, Kyle D.,Connell, Brian T.
supporting information; experimental part, p. 1715 - 1717 (2010/07/06)
A very efficient method for the direct α-methylenation of carbonyl compounds, with yields up to 99%, utilizing paraformaldehyde, diisopropylammonium trifluoroacetate, and catalytic acid or base, is presented.
Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
Li, Hongmei,Asberom, Theodros,Bara, Thomas A.,Clader, John W.,Greenlee, William J.,Josien, Hubert B.,McBriar, Mark D.,Nomeir, Amin,Pissarnitski, Dmitri A.,Rajagopalan, Murali,Xu, Ruo,Zhao, Zhiqiang,Song, Lixin,Zhang, Lili
, p. 6290 - 6294 (2008/09/17)
Development of cis-2,4,6-trisubstituted piperidine N-arylsulfonamides as γ-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported.
Studies on the thermal generation and reactivity of a class of (σ,π)-1,4-biradicals
Myers, Andrew G.,Dragovich, Peter S.,Kuo, Elaine Y.
, p. 9369 - 9386 (2007/10/02)
(Z)-1,2,4-Heptatrien-6-yne and compounds that contain the (Z)-allene-ene-yne functional group or that form it in a serial reaction sequence were prepared and shown to undergo a mild thermal reaction to form aromatic products. All observations suggest that
