144564-16-9Relevant academic research and scientific papers
Molecular building kit of fused-proline-derived peptide mimetics allowing specific adjustment of the dihedral Ψ angle
Einsiedel, Juergen,Lanig, Harald,Waibel, Reiner,Gmeiner, Peter
, p. 9102 - 9113 (2008/03/13)
(Chemical Equation Presented) Proline-derived peptide mimetics have become an area of paramount importance in peptide and protein chemistry. Since protein crystal structures frequently display Ψ angles of 140-170° for prolyl moieties, our intention was to
Synthesis of Homochiral R-Baclofen from S-Glutamic Acid
Herdeis, C.,Hubmann, H. P.
, p. 1213 - 1221 (2007/10/02)
A streoselective synthesis of R-Baclofen is presented starting from S-pyroglutamic acid derivative 3.The key steps are the 1,4-conjugate addition of Grignard cuprate (p-ClPh)2CuMgCl to 3 and Barton-Decarboxylation of 6e to 7e.
