1445703-83-2

Upstream product

• 1415218-09-5 4-methylphenyl 2,3-di-O-benzoyl-1-thio-β-D-xylopyranoside 
• 149707-75-5 2,3,4,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate 
• 67803-94-5 4-methylphenyl 1-thio-β-D-xylopyranoside 
• 1445703-80-9 1-(4-tolyl)thio-2,3-O-isopropylidene-4-O-(1-methoxy-1-methylethyl)-β-D-xylopyranoside 
• 1415218-00-6 1-(4-tolyl)thio-2,3-O-isopropylidene-β-D-xylopyranoside 
• 1445703-81-0 1-(4-tolyl)thio-4-O-acetyl-β-D-xylopyranoside 
• 98-88-4 benzoyl chloride 
• 1445703-82-1 1-(4-tolyl)thio-2,3-di-O-benzoyl-4-O-acetyl-β-D-xylopyranoside 

Downstream Products

• 1352410-43-5 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1 → 4)-2,3-di-O-benzoyl-β-D-xylopyranoside trichloroacetimidate 

Relevant academic research and scientific papers

Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives

Twenty-six naturally occurring oleanolic acid saponins and their derivatives, 16 of which were synthesized in this study, were preliminarily evaluated against human cancer cells. From SAR studies, the presence of α-l-rhamnosyl residue at the terminal of both C-3 and C-28 position for oleanolic acid bidesmosides was important to enhance cytotoxicity, and introducing more sugar residues at C3-OH of compound 12 with C-28 carboxylic acid is a favorable modification to ameliorate the anticancer activity. Furthermore, α-l-rhamnosyl moiety linked to C2-OH of the first monosaccharide (α-l-alabinose, β-d-xylose, β-d-galactose or β-d-glucose) in C3-OH of oleanolic acid was helpful to improve the cytotoxicity. According to the predicted log P values, lipophilicity of the synthesized saponins was not an important factor for cytotoxicity.