1445760-46-2

Upstream product

• 1445760-34-8 (1''R,2''S,5''S,6''S)-1,3-bis-(1'-(4''-bromo-5'',6''-isopropylidenedioxy-cyclohexa-3''-ene-1''-ol-2''-yl)-1’-H-[1',2',3']-triazol-4'-yl)-benzene 
• 1785-61-1 1,3-diethynylbenzene 
• 171916-75-9 (1R,2S,5S,6S)-2-azido-4-bromo-5,6-isopropylidenedioxycyclohexa-3-ene-1-ol 

Relevant academic research and scientific papers

Synthesis and preliminary biological evaluation of a compound library of triazolylcyclitols

A small library of compounds was prepared by a combination of toluene dioxygenase (TDO)-catalyzed enzymatic dihydroxylation and copper(I)-catalyzed Hüisgen cycloaddition. Some compounds were obtained by coupling an alkyne and a conduritol derivative, while more complex structures were obtained by a double Hüisgen reaction of a dialkyne and two molecules of the cyclitol. The compounds were fully characterized and subjected to preliminary biological screening.