1445828-44-3Relevant articles and documents
Co(iii)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: Its application in the synthesis of ICI-118,551, an anti-hypertensive agent
Karabal, Pratibha U.,Kamble, Dayanand A.,Sudalai, Arumugam
, p. 2349 - 2355 (2014/04/03)
The salen Co(iii)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti- or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a β-blocker, in a highly optically pure form (99% ee). the Partner Organisations 2014.
PHENOLYTIC KINETIC RESOLUTION OF AZIDO AND ALKOXY EPOXIDES
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Page/Page column 17; 29, (2013/07/05)
Disclosed herein is a single step catalytic process for the production of enantiomerically pure ?-Aryloxy-?'-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A). Formula A