1445849-53-5Relevant academic research and scientific papers
Monomer compounds comprising uracil group, Organic layers comprising the cross-linked of the monomer compounds, and Organic electronic device comprising the organic layers
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Paragraph 0277-0278; 0282-0283, (2020/08/01)
The present invention provides a pyrimidine-based functional group-containing monomolecular compound represented by chemical formula 1 of Ar-(R_1-R_2-Py)_n as a material for an organic layer of an organic electronic device. The compound can form an organic layer within a short time through photo-curing at room temperature. In chemical formula 1, n is 2-10; Ar is a substituted or non-substituted C_6-C_60 aryl group, or a substituted or non-substituted C_3-C_60 heteroaryl group having an n-valent linking group; each of R_1 and R_2 independently represents a single bond, -O-, a substituted or non-substituted C_6-C_30 arylene group, a substituted or non-substituted C_3-C_30 heteroarylene group, a substituted or non-substituted C_1-C_10 alkylene group, a substituted or non-substituted C_1-C10 alkoxylene group, a substituted or non-substituted amide group, or a substituted or non-substituted amine group; and Py is a monovalent linking group derived from a pyrimidine-based functional group.COPYRIGHT KIPO 2020
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Babkov, Denis A.,Khandazhinskaya, Anastasia L.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Seley-Radtke, Katherine L.,Novikov, Mikhail S.
, p. 7035 - 7044 (2015/11/11)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
Novikov, Mikhail S.,Babkov, Denis A.,Paramonova, Maria P.,Khandazhinskaya, Anastasia L.,Ozerov, Alexander A.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Balzarini, Jan,Seley-Radtke, Katherine L.
, p. 4151 - 4157 (2013/07/27)
HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12 μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.
