1445877-12-2

Upstream product

• 14432-11-2 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide 
• 6863-46-3 Imidazo<4,5-b>pyridine 4-Oxide 
• 261952-16-3 1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene 
• 24485-01-6 5,7-dichloro-3H-imidazo<4,5-b>pyrimidine 
• 273-21-2 1H-Imidazo[4,5-b]pyridine 

Downstream Products

• 1445877-13-3 5-chloro-7-(methyloxy)-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-imidazo[4,5-b]pyridine 
• 1445877-04-2 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholino-3H-imidazo[4,5-b]pyridin-7-ol 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS

This invention relates to the use of imidizopyridine derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of imidizopyridines in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective imidizopyridine compounds for treating cancer.