6863-46-3

Basic information

• Product Name: 3H-Imidazo[4,5-b]pyridine, 4-oxide
• Synonyms: 3H-Imidazo[4,5-b]pyridine, 4-oxide;1-Deazapurine N3-oxide;1H-Imidazo[4,5-b]pyridine 4-oxide;4-Oxide-3H-iMidazo[4,5-b]pyridine;4-hydroxyimidazo[4,5-b]pyridine
• CAS NO: 6863-46-3
• Molecular Formula: C₆H₅N₃O
• Molecular Weight: 135.13
• Mol File: 6863-46-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 252℃(DEC.)
• Appearance: /
• Density: 1.51
• CAS DataBase Reference: 3H-Imidazo[4,5-b]pyridine, 4-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Imidazo[4,5-b]pyridine, 4-oxide(6863-46-3)
• EPA Substance Registry System: 3H-Imidazo[4,5-b]pyridine, 4-oxide(6863-46-3)

Safety Data

• Hazardous Substances Data: 6863-46-3(Hazardous Substances Data)

Usage

General Description

3H-Imidazo[4,5-b]pyridine, 4-oxide, also known as 4-IPNO, is a chemical compound that is commonly used in pharmacological research. It is a heterocyclic compound with a five-membered ring containing nitrogen and oxygen. 4-IPNO has been studied for its potential biological activities, including its role as an oxalate decarboxylase enzyme inhibitor. It has also been investigated for its potential as an antioxidant and anti-inflammatory agent. Additionally, 4-IPNO has shown potential as a modulator of cellular signaling pathways and has been studied for its potential use in cancer therapy. Overall, 4-IPNO is a versatile and important compound in pharmaceutical research with various potential biological activities.

Upstream product

• 273-21-2 3H-imidazo[4,5-b]pyridine 
• 452-58-4 2,3-Diaminopyridine 
• 273-21-2 1H-Imidazo[4,5-b]pyridine 

Downstream Products

• 14432-11-2 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide 
• 24485-01-6 5,7-dichloro-3H-imidazo<4,5-b>pyrimidine 
• 1445877-12-2 5,7-dichloro-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-imidazo[4,5-b]pyridine 
• 1445877-04-2 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholino-3H-imidazo[4,5-b]pyridin-7-ol 
• 1065479-06-2 N-((8-chloro-2-(2-chlorophenyl)-quinolin-3-yl)methyl)-3H-imidazo[4,5-b]pyridin-7-amine 
• 878011-41-7 tert-butyl 7-chloro-3H-imidazo[4,5-b]pyridine-3-carboxylate 
• 1137089-70-3 C₁₄H₁₃N₃O 
• 1137089-69-0 C₁₄H₁₃N₃O 
• 1137089-67-8 3-benzyl-3H-imidazo[4,5-b]pyridine 4-oxide 
• 1137089-66-7 1-benzyl-1H-imidazo[4,5-b]pyridine 4-oxide 
• 6980-11-6 7-chloro-3H-imidazo<4,5-b>pyridine 
• 83472-65-5 5-chloro-3-methyl-3H-imidazo[4,5-b]pyridine 
• 6980-13-8 7-chloro-3-β-D-ribofuranosyl-3H-imidazo<4,5-b>pyridine 
• 929533-19-7 3-benzyl-5,7-diphenyl-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Fluorescing Isofunctional Ribonucleosides: Assessing Adenosine Deaminase Activity and Inhibition

The enzymatic conversion of isothiazolo[4,3-d]pyrimidine-based adenosine (tzA) and 2-aminoadenosine (tz2-AA) analogues to the corresponding isothiazolo[4,3-d]pyrimidine-based inosine (tzI) and guanosine (tzG) derivatives is evaluated and compared to the conversion of native adenosine to inosine. Henri–Michaelis–Menten analyses provides the foundation for a high-throughput screening assay, and the efficacy of the assay is showcased by fluorescence-based analysis of tzA conversion to tzI in the presence of known and newly synthesized inhibitors.

IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS

This invention relates to the use of imidizopyridine derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of imidizopyridines in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective imidizopyridine compounds for treating cancer.

Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter

The syntheses of new N-polysubstituted imidazo[4,5-b]pyridine-7-one (IP, 5 and 8a-8f) and indazole-4,7-dione (ID, 9 and 10) derivatives are described. The binding affinity of IP and ID towards the recombinant Nucleotide Binding Domain NBD1 of Cryptosporidium parvum CpABC3 was evaluated by intrinsic fluorescence quenching. IP induced a moderate quenching of the intrinsic fluorescence of H6-NBD1 whereas IDs 9 and 10 showed a binding affinity comparable to the ATP analogue TNP-ATP. In addition, 8d, 8e and 10 were shown to be competitive inhibitors of the ATPase activity, but with low affinity. These compounds could thus act like some flavonoid derivatives, which can partly overlap both the nucleotide-binding site and the adjacent hydrophobic steroid-binding region of mammalian P-glycoproteins.