1445949-47-2

Upstream product

• 1445949-46-1 N,N'-((2S,3S)-1,4-bis(benzyloxy)butane-2,3-diyl)bis(2-fluoro-3-(trifluoromethyl)benzamide) 
• 208173-19-7 2-fluoro-3-trifluoromethylbenzoyl chloride 

Downstream Products

• 1445949-48-3 (4S,4'S)-2,2'-bis(2-fluoro-3-(trifluoromethyl)phenyl)-4,4',5,5'-tetrahydro-4,4'-bioxazole 
• 1445949-49-4 (4S,4'S)-2,2'-bis(2-(benzyloxy)-3-(trifluoromethyl)phenyl)-4,4',5,5'-tetrahydro-4,4'-bioxazole 
• 1445949-60-9 6,6'-((4S,4'S)-4,4',5,5'-tetrahydro-4,4'-bioxazole-2,2'-diyl)bis(2-(trifluoromethyl)phenol) 

Relevant academic research and scientific papers

Novel O,N,N,O-tetradentate ligand from tartaric acid

A new class of highly stable O,N,N,O-tetradentate bioxazoline ligands were synthesized from l-tartaric acid. Exploration of those ligands in Pd-catalyzed asymmetric allylic alkylation yielded alkylated product up to 96% ee. Necessity of additional chelation to obtain high enantioselectivity was also demonstrated. Structural modifications of this ligand might result in identification of a novel privileged chiral ligand from an inexpensive chiral pool.