1445973-19-2

Basic information

• Product Name: C₉₀H₁₂₇N₂₅O₂₄S₂
• CAS NO: 1445973-19-2
• Molecular Weight: 2007.28
• Mol File: 1445973-19-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₉₀H₁₂₇N₂₅O₂₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₉₀H₁₂₇N₂₅O₂₄S₂(1445973-19-2)
• EPA Substance Registry System: C₉₀H₁₂₇N₂₅O₂₄S₂(1445973-19-2)

Safety Data

• Hazardous Substances Data: 1445973-19-2(Hazardous Substances Data)

Upstream product

• 159610-89-6 6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid 
• 1048377-78-1 C₃₆H₄₃N₅O₈S 
• 83961-81-3 S-phenacyl-L-cysteine 
• 120791-76-6 N-fluorenylmethoxycarbonyl-threonine-tert-butyl ester 
• 133852-23-0 tert-butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate 

Relevant articles and documents

The phenacyl group as an efficient thiol protecting group in a peptide condensation reaction by the thioester method

One of the condensation methods for the preparation of long-chain peptides, the so-called thioester method requires protecting groups for amino and thiol groups for regioselective ligation. In this study, we demonstrated that the phenacyl (Pac) group acts as an efficient protecting group of cysteine side chains. We synthesized a cysteine derivative carrying the Pac group at the side chain sulfur atom, and Pac-containing peptides and peptide thioesters were synthesized using it by the ordinary 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis strategy. Pac-containing peptide segments could be condensed by the thioester method. After the condensation reaction, Pac groups could be removed by Zn/AcOH treatment. In addition, the azido group, which was used for the protection of lysine side chains, was simultaneously converted into an amino group, demonstrating that this protecting group scheme simplified the deprotecting reaction after the peptide condensation reaction to a single step. The Royal Society of Chemistry 2013.