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120791-76-6

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120791-76-6 Usage

General Description

NALPHA-FMOC-L-THREONINE TERT-BUTYL ESTER is a chemical compound used in peptide synthesis and organic chemistry research. It is the tert-butyl ester derivative of Nalpha-Fmoc-L-threonine, a derivative of the amino acid threonine that is commonly used in the production of peptides. NALPHA-FMOC-L-THREONINE TERT-BUTYL ESTER is often used as a building block in the synthesis of complex peptide structures for applications in drug development, biochemistry, and molecular biology. NALPHA-FMOC-L-THREONINE TERT-BUTYL ESTER is a versatile compound that can be easily manipulated in the laboratory to access a wide range of peptide derivatives and analogs. Its stability and ease of handling make it a valuable tool for researchers working in the field of organic and peptide chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 120791-76-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,7,9 and 1 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 120791-76:
(8*1)+(7*2)+(6*0)+(5*7)+(4*9)+(3*1)+(2*7)+(1*6)=116
116 % 10 = 6
So 120791-76-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H27NO5/c1-14(25)20(21(26)29-23(2,3)4)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20,25H,13H2,1-4H3,(H,24,27)/t14-,20+/m1/s1

120791-76-6 Well-known Company Product Price

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  • TCI America

  • (F0517)  Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine tert-Butyl Ester  >98.0%(HPLC)(N)

  • 120791-76-6

  • 1g

  • 990.00CNY

  • Detail
  • TCI America

  • (F0517)  Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine tert-Butyl Ester  >98.0%(HPLC)(N)

  • 120791-76-6

  • 5g

  • 3,450.00CNY

  • Detail

120791-76-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxybutanoate

1.2 Other means of identification

Product number -
Other names Nalpha-Fmoc-L-threonine tert-Butyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120791-76-6 SDS

120791-76-6Relevant articles and documents

Solid-Phase Synthesis of a Tumor-Associated Sialyl-TN Antigen Glycopeptide with a Partial Sequence of the "Tandem Repeat" of the MUC-1 Mucin

Liebe, Beate,Kunz, Horst

, p. 618 - 621 (1997)

-

Polypeptide raw material N-fluorenylmethoxycarbonyl-O-tert-butyl threonine preparation method

-

Paragraph 0012-0015, (2019/01/23)

The invention discloses a polypeptide raw material N-fluorenylmethoxycarbonyl-O-tert-butyl threonine preparation method, and mainly solves the technical problems of complexity, long cycle, more wastegas, waste water and industrial residues, high cost, high dangerousness and the like in an original process. The preparation method includes the steps: first, suspending threonine in methanol, reducing temperature, dropping thionyl chloride and then removing solvents by concentration after temperature reaction to obtain threonine methyl ester hydrochloride; second, dissolving the threonine methylester hydrochloride in methylene dichloride, leading in isobutene, concentrating sulfuric acid and performing sealed reaction treatment to obtain oily O-tert-butyl threonine methyl ester; third, dissolving the O-tert-butyl threonine methyl ester in water and acetone, adding sodium hydroxide, enabling pH (potential of hydrogen) to be 11-12, performing reaction to obtain O-tert-butyl threonine solution, adding 9-fluorenylmethyl-N-succinimidyl carbonate, maintaining the pH of 8-9 of a system by the aid of alkali liquor, performing washing acidification extraction after reaction and performing treatment to obtain N-fluorenylmethoxycarbonyl-O-tert-butyl threonine serving as a final product.

Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids

Tavernaro, Isabella,Hartmann, Sebastian,Sommer, Laura,Hausmann, Heike,Rohner, Christian,Ruehl, Martin,Hoffmann-Roeder, Anja,Schlecht, Sabine

, p. 81 - 97 (2015/01/16)

The mucin MUC1 is a glycoprotein involved in fundamental biological processes, which can be found over-expressed and with a distinctly altered glycan pattern on epithelial tumor cells; thus it is a promising target structure in the quest for effective carbohydrate-based cancer vaccines and immunotherapeutics. Natural glycopeptide antigens indicate only a low immunogenicity and a T-cell independent immune response; however, this major drawback can be overcome by coupling of glycopeptide antigens multivalently to immunostimulating carrier platforms. In particular, gold nanoparticles are well suited as templates for the multivalent presentation of glycopeptide antigens, due to their remarkably high surface-to-volume ratio in combination with their high biostability. In this work the synthesis of novel MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes are presented. In addition, the development of a new dot-blot immunoassay to test the potential antigen-antibody binding is introduced.

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