1445975-53-0Relevant academic research and scientific papers
Development of an efficient and sustainable synthesis of 2-(3-methyl-1: H-1,2,4-triazol-1-yl) acetic acid under continuous-flow conditions
Abele, Stefan,Friedli, Astrid,Kohler, Philipp,Prud'homme, Alice,Richard-Bildstein, Sylvia,Tortoioli, Simone,Vilé, Gianvito
, p. 3748 - 3758 (2020/07/09)
A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl) acetic acid is reported, which features an efficient construction of the triazole ring under flow conditions. This continuous, one-pot method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatography and isolation steps. Compared to the earlier batch routes, higher yields were achieved in a flow reactor. In addition, a highly-energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles were prepared under the described conditions, confirming that the methodology could find useful applications for the rapid and sustainable construction of differentially-functionalized 1,2,4-triazoles.
Multicomponent synthesis of 1-aryl 1,2,4-triazoles
Tam, Annie,Armstrong, Ian S.,La Cruz, Thomas E.
supporting information, p. 3586 - 3589 (2013/08/23)
A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position of the nitrogen atoms in the newly formed ring was established by 15N labeling and NMR spectroscopy.
