144599-95-1

Basic information

• Product Name: BOC-TRP(BOC)-OH
• Synonyms: N,N'-DI-(T-BUTYLOXYCARBONYL)-L-TRYPTOPHANE;N,N'-DI-TERT-BUTYLOXYCARBONYL-L-TRYPTOPHAN;N-ALPHA-T-BOC-N-IN-T-BOC-L-TRYPOPHAN;N-ALPHA-T-BUTYLOXYCARBONYL-N-IN-T-BUTOXYCARBONYL-L-TRYPTOPHAN;BOC-TRYPTOPHAN(BOC)-OH;BOC-TRP(BOC)-OH;BOC-L-TRP(BOC)-OH;BOC-N-IN-BOC-L-TRYPTOPHAN
• CAS NO: 144599-95-1
• Molecular Formula: C21H28N2O6
• Molecular Weight: 404.46
• Product Categories: Tryptophan [Trp, W];Boc-Amino Acids and Derivative
• Mol File: 144599-95-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.202 g/cm³
• Storage Temp.: -20°C
• Solubility: Soluble in dimethylformamide (1 mmole in 2 ml).
• CAS DataBase Reference: BOC-TRP(BOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-TRP(BOC)-OH(144599-95-1)
• EPA Substance Registry System: BOC-TRP(BOC)-OH(144599-95-1)

Safety Data

• Hazardous Substances Data: 144599-95-1(Hazardous Substances Data)

Usage

Uses

N-Boc-1-Boc-L-tryptophan is generally used as a intermediate in pharmaceutical and chemical research.

Upstream product

• 689232-06-2 tert-Butyl 3-(2-((tert-Butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5619-09-0 methyl tryptophanate hydrochloride 

Downstream Products

• 918902-48-4 Boc-Trp(Boc)-Phe-OMe 
• 82597-82-8 cyclo(L-tryptophyl-L-phenylalanyl) 
• 198632-67-6 (S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester 
• 1588517-15-0 tert-butyl 3-(2-((tert-butoxycarbonyl)amino)-2-(4-cyanophenyl)ethyl)-1H-indole-1-carboxylate 
• 88831-09-8 L-Tryptophan-L-arginine 

Relevant articles and documents

Mild and selective deprotection of carbamates with Bu4NF

A new mild method allowing the removal of carbamates using TBAF in THF is reported. Reactions were performed on indole, indoline, N-methyl aniline, aniline and tryptamine derivatives. The observed selectivity according to the carbamates or the substrates is discussed. A mechanism is postulated. Graphical Abstract