5619-09-0

Basic information

• Product Name: DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE
• Synonyms: H-DL-TRP-OME HCL;DL-TRYPTOPHAN METHYL ESTER HCL;DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE;DL-TRYPTOPHAN-OME HCL;METHYL 2-AMINO-3-(1H-INDOL-3-YL)PROPANOATE HYDROCHLORIDE;TIMTEC-BB SBB003122;methyl2-amino-3-(1H-indol-3-yl)propanoateHCl;DL-Methyl Tryptophanate Monohydrochloride
• CAS NO: 5619-09-0
• Molecular Formula: C₁₂H₁₄N₂O₂*ClH
• Molecular Weight: 254.71
• EINECS: 1533716-785-6
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
• Mol File: 5619-09-0.mol
• Article Data: 106

Chemical Properties

• Melting Point: 221-222
• Boiling Point: 390.6 °C at 760 mmHg
• Flash Point: 190 °C
• Appearance: Off-white to white/Solid
• Density: 1.245g/cm3
• Vapor Pressure: 2.62E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Methanol, Water
• CAS DataBase Reference: DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE(5619-09-0)
• EPA Substance Registry System: DL-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE(5619-09-0)

Safety Data

• Hazard Codes: Xi,Xn
• Hazardous Substances Data: 5619-09-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 5619-09-0 differently. You can refer to the following data:
1. Amino acid derivative， D,L-Tryptophan Methyl Ester Hydrochloride may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550)
2. Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550).

InChI:InChI=1/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H

Upstream product

• 73-22-3 L-Tryptophan 
• 67-56-1 methanol 
• 141595-98-4 D-tryptophan benzyl ester 
• 153-94-6 D-tryptophan 
• 5619-09-0 methyl tryptophanate hydrochloride 
• 153-94-6 D-tryptophan 
• 6159-33-7 L-tryptophan hydrochloride 
• 141215-69-2 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoate 
• 1198605-52-5 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate 
• 54-12-6 Trp 
• 120-72-9 indole 
• 118553-32-5 Methyl N-(diphenylmethylene)-D,L-tryptophanates 

Downstream Products

• 14437-50-4 (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-3-(1H-indol-3-yl)propanoate 
• 82774-92-3 Z-L-Arg(H*HCl)-L-Trp-OMe 
• 107326-76-1 Boc-D-Lys(Z)-Trp-OCH₃ 
• 98385-60-5 Z-Asp(O-t-Bu)-Trp-OMe 
• 138207-77-9 (S)-2-((2S,3S)-3,7-Bis-benzyloxycarbonylamino-2-hydroxy-heptanoylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 138257-68-8 (S)-2-((2R,3R)-3,7-Bis-benzyloxycarbonylamino-2-hydroxy-heptanoylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 138257-69-9 (S)-2-((2S,3R)-3,7-Bis-benzyloxycarbonylamino-2-hydroxy-heptanoylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 82842-58-8 Nps-Lys(Z)-Trp-OMe 
• 17689-58-6 N-(benzyloxycarbonyl)-L-tryptophanyl-L-tryptophan methyl ester 
• 81444-73-7 N-(benzyloxycarbonyl)-D-tryptophanyl-L-tryptophan methyl ester 
• 121838-57-1 Me₂-Orn(Z)-Trp-OMe 
• 121838-56-0 Me₂-Lys(Z)-Trp-OMe 
• 154-09-6 L-tryptophanol 
• 20696-57-5 L-tryptophanamide 

Relevant articles and documents

(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative as well as preparation method and application thereof

The invention discloses a (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative shown as a formula (I) or an optical isomer, a diastereomer and racemate mixture and pharmaceutically acceptable salt thereof as well as a preparation method and application of the (2S, 3R)-3-amino-2-hydroxy-4-phenylbutyrylamide derivative. It is shown by comparison of results of a positive control group and a model group on lymphedema prevention experiments that the compound disclosed in the invention shows obvious anti-edema activity.

Synthesis and anti-tumor activity of marine alkaloids

Marine alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure–activity relationship of various compounds were discussed.

Preparation method of phosphodiesterase inhibitor

The invention discloses a preparation method of a phosphodiesterase inhibitor and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: starting the raw material 1 and methanol to prepare the intermediate I without adding organic solvent crystallization. After the series of centrifugation, washing and drying, the intermediate II is directly condensed and cyclized with piperonal, and a final product tadalafil is prepared by chloroacetylation, aminolysis and refining steps. The method improves the product yield and quality, greatly shortens the reaction period, reduces the operation steps and the production cost, and is suitable for industrial mass production.